The involvement of cyclin D1 degradation through GSK3 beta-me diate d threonine-286 phosphorylation-dependent nuclear export in anti-cancer activity of mulberry root bark extracts

摘要

Background: Mulberry root bark was shown to induce cyclin D1 proteasomal degradation in the human colorectal cancer cells. Still, the molecular mechanisms whereby mulberry root bark induces cyclin D1 proteasomal degradation remain largely unknown.