optically active halogenhydrinderivat and process for the production of optically active epoxyalkoholderivats thereof

摘要

A process by which an optically active epoxy alcohol derivative useful as an intermediate for medicines can be easily and industrially safely produced from an inexpensively available material; and a halohydrin derivative which is an important novel intermediate therefor. Also provided is a process for producing an intermediate for triazole type antifungal agents through a small number of steps, which comprises reacting the halohydrin derivative with a triazolesulfonamide. An optically active, substituted propionic ester derivative is reacted with a haloacetic acid derivative in the presence of a base to obtain an optically active haloketone derivative and this derivative is reacted with an arylmetal compound to stereoselectively obtain a halohydrin derivative. This halohydrin derivative is subjected to elimination of the substituent present on the hydroxy group and to epoxidation with a base to produce an optically active epoxy alcohol derivative.