Agents for suppressing Neurological Symptoms caused by Peripheral nervous disorder induced by anticancer agents

摘要

Claim 1: a preparation for inhibiting peripheral nerve disorders caused by anticancer substances, which is characterized by comprising a compound represented by formula (1), wherein R is a liquefied carbide group with a selective alternative, (2) A group of aromatic compounds with alternative substitutes, (3) a heterocycle group with alternative substitutes, (4) a group with formula representative: - or1, wherein R1 is a hydrogen atom, or a propylene group with alternative substitutes,O (5) a group represented by R-N (r1b) (r1c) formula, in which r1b and r1c are the same or different, each group is a hydrogen atom or a liquefied carbide group with alternative substitutes, R0 is a hydrogen atom or a liquefied carbide group, or R and R0 can be combined to form a link, Ring A1 is an optional alternative to ring a, consisting of 1 to 4 alternatives selected from the group, including (I) a liquefied hydrogen carbon group with alternatives and (two) an aromatic hydrocarbon group with alternatives,(III) a formula group: - R11, wherein R11 is a hydrogen atom or a liquefied carbide group of alternative products; and (4) a halogenated atom and (IV) a hydrogen halide atom, AR is an aromatic group of alternative products, and a formula group (2),This is a group represented by formula (3) or (4), n is a whole, from 1 to 4, or a salt or a sample, or a compound represented by formula (5), wherein R1 'is a liquefied carbide group, which can be replaced optionally, (2) an aromatic hydrocarbon group, which can be replaced optionally, (3) An alternative heterocyclic group, (4) a group represented by the formula: - or1a 'where R1a' is a hydrogen atom or a liquefied carbide group, alternative,O (5) is a group consisting of the following formula: n (r1b) (r1c '), where r1b' and r1c 'are equal or different, each of which is a hydrogen atom or a liquefied carbide group with a selective substitute, X is a methylene, NH, a sulfur atom or an oxygen atom, A-ring A1 is a ring composed of 5 to 8 members. One to four substitutes selected from this group can be selected, including (1) an propylene carbide group with substitutes, and (2) an aromatic hydrocarbon group. Succedaneum(III) a formula group: - R2 'in which R2' is a hydrogen atom or an alternative liquefied carbide group, and (4) a halogenated atom, and (IV) a halogenated atom, AR 'is an aromatic hydrocarbon group, alternative, The group represented by the formula (6) is the group represented by the formula (7) or (8),S is an integer 0 to 2, t is an integer 1 to 3, and the total number of S and t is 4 or less; if x is methylene, then y should be an alternative methylene, or a salt or a preamble.