h-factor-targeted disease treatment

摘要

H FACTOR-DIRECTED DISEASE TREATMENT OF THE COMPLEMENT.The invention provides a CR2-FH molecule comprising a CR2 moiety comprising 0R2 protein or a fragment thereof and an FH moiety comprising a H factor protein or fragment thereof, and compositions. pharmaceuticals comprising a CR2-FH molecule. Also provided are methods of using the compositions for treating diseases in which the alternative complement pathway is implicated, such as, for example, age-related macular degeneration, rheumatoid arthritis, and ischemia re-infusion.