morphine glucuronide derivatives of 6, their preparation and their therapeutic application

摘要

the present invention relates to derivatives of morphine 6 glucuronide of formula (i): in which: r1 is a substituted heteroaromatic ring group on 5 may by one or more substituents selected from the halogen atoms, alkyl groups, halogen, c1-c4) halo, hydroxyl, alkyl (c1-c4), halo (c1-c4) alkyloxy, (c1-c4) alkyloxy, aryl, aryl alkyl, c1-c4).the aryl group may be substituted by one or more groups selected from groups (c1 - c4) alkyl, halo alkyl (c1-c4), hydroxyl (c1-c4) alkyloxy, rule base or acid addition salt, a hydrate, and the state or the solvate. the present invention is the preparation process and application in therapeutics.