首页> 外国专利> NEW DERIVATIVES OF BENZOBCHROMENO-NAPHTHYRIDIN-1-ONE AND PYRANO2'3':7,8QUINO2,3-BQUINOXALIN-7-ONE, METHOD OF PREPARING SAID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES

NEW DERIVATIVES OF BENZOBCHROMENO-NAPHTHYRIDIN-1-ONE AND PYRANO2'3':7,8QUINO2,3-BQUINOXALIN-7-ONE, METHOD OF PREPARING SAID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES

机译:苯并[B]色氮萘啶-1-酮和吡喃并[2'3':7,8]喹诺[2,3-B]喹诺沙林-7-酮的新衍生物,制备所述衍生物和含有上述成分的药物组合物的方法衍生品

摘要

The present invention relates to compounds of formula (I): (see formula I) in which: .cndot. B1, B2 represent a carbon or nitrogen atom, .cndot. X, Y, X1 and Y1 represent a group chosen from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, trihaloalkyl and NR a R b in which R a and R b are as defined in the description, .cndot. R1 represents a hydrogen atom or an alkyl group, .cndot. R2 represents a group chosen from hydrogen atom, alkyl, -OR "a, NR'a R'b, -OT a-OR" a, -NR "a-T a-NR'a R'b, NR" aC (O) -T a H, -OC (O) -T a H, -OT a-NR a'R b ', -NR "a-T a-OR" a-NR "a-T a-CO2R "a, -NR" aC (O) -T a-NR'a R'b in which R'a, R'b, R "a and T a are as defined in the description, .cndot. R3, R4 represent a hydrogen atom or an alkyl group, .cndot. A represents a group of formula -CH (R5) -CH (R6) -, -CH = C (R7) -, -C (R7) = CH-, -C (O) -CH (R8) -, -CH (R8) -C (O) - in which R5, R6, R7 and R8 are as defined in the description, their isomers defined in the description, N-oxides, as well as their addition salts with an acid or a pharmaceutically acceptable base. The invention also relates to pharmaceutical compositions containing the compounds of formula (I).
机译:本发明涉及式(I)的化合物:(参见式I)其中:.cndot。 B 1,B 2代表碳或氮原子。 X,Y,X 1和Y 1代表选自氢,卤素,羟基,烷氧基,硝基,氰基,三卤代烷基和NR a R b的基团,其中R a和R b如说明书中的定义。 R 1代表氢原子或烷基。 R 2代表选自氢原子,烷基,-OR“ a,NR'a R'b,-OT a-OR” a,-NR“ aTA-NR'a R'b,NR” aC(O)的基团-T a H,-OC(O)-T a H,-OT a-NR a'R b',-NR“ aT a-OR” a-NR“ aT a-CO2R” a,-NR“ aC( O)-T a-NR'a R'b,其中R'a,R'b,R” a和T a如描述.cndot中所定义。 R 3,R 4代表氢原子或烷基。 A代表一组式-CH(R5)-CH(R6)-,-CH = C(R7)-,-C(R7)= CH-,-C(O)-CH(R8)-,-CH (R8)-C(O)-其中R5,R6,R7和R8如说明书中所定义,其异构体如说明书中所定义,N-氧化物以及它们与酸或药学上可接受的碱的加成盐。本发明还涉及含有式(I)化合物的药物组合物。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号