NOVEL ARTIFICIAL NUCLEIC ACIDS OF N-O BOND CROSSLINKAGE TYPE

摘要

It is intended to provide oligonucleotide analogs usable in, for exmaple, the antisense method which are highly tolerant to enzymes, have a strong and selective binding affinity for a single-stranded RNA and also are highly capable of forming a triple-strand in a double-stranded DNA, and nucleoside analogs useful for producing the same. Namely, a nucleoside analog which is a compound represented by the following general formula (I) or its salt and an oligonucleotide analog containing one or more of the same:wherein Base represents an optionally substituted aromatic heterocyclic group, etc.: R1, R2 and R3 represent each a hydrogen atom, an amino-protecting group, a hydroyl-protecting group, a phosphate group or -P (R4)R5 [wherein R4 and R5 represent each a hydroxyl group, a protecting group, an optionally protected mercapto group, etc,]; m is from 0 to 2; and n is from 1 to 3.