METHOD OF DETERMINING PROTEIN BINDING CHARACTERISTICS OF A DRUG CANDIDATE

摘要

Provided are systems and methods for determining pharmacokinetic and pharmacodynamic profiles for a potential drug candidate, such as a small molecule or ligand. In various embodiments, the disclosed systems and methods may combine a device, such as a differential scanning calorimeter (DSC), with a computer that employs software for calculating thermodynamic parameters such as enthalpies of transition for a combination of molecules within a mixture. Various embodiments, includes methods for determining a drug candidate or ligand interaction with one or more biomolecules such as, e.g., human serum albumin or other blood plasma proteins.