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METHOD OF MODIFYING SURFACE OF PANCREATIC ISLETS USING HETEROFUNCTIONAL-HIGH ORDER STRUCTURAL PEG WITH BIOACTIVE COMPLEX AND PANCREATIC ISLETS HAVING MODIFIED SURFACE USING THE METHOD
METHOD OF MODIFYING SURFACE OF PANCREATIC ISLETS USING HETEROFUNCTIONAL-HIGH ORDER STRUCTURAL PEG WITH BIOACTIVE COMPLEX AND PANCREATIC ISLETS HAVING MODIFIED SURFACE USING THE METHOD
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机译:具有生物活性复合物的功能性高阶结构PEG修饰胰岛表面的方法及使用该方法修饰胰岛的胰岛
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摘要
PURPOSE: A method for modifying the surface of pancreatic islets is provided to effectively reduce immune response and to induce antithrombogenicity effect. CONSTITUTION: A method for modifying the surface of pancreatic islet comprises: a step of activating PEG or derivatives thereof for conjugation of PEG or derivatives thereof on the surface of the pancreatic islet; a step of conjugating the activated PEG or derivatives thereof with an amine group on the surface; and a step of conjugating the terminal function groups of the PEG or derivatives with the bioactive complex. The bioactive complex is conjugated with heparin or derivatives thereof, and bioactivation materials. [Reference numerals] (AA) Pancreatic islet cells; (BB) Heparin catechol; (CC) 8-armed star shaped PEG
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