Method of modifying surface of pancreatic islets using heterofunctional-high order structural PEG with bioactive complex and pancreatic islets having modified surface using the method

摘要

PURPOSE: A method for modifying the surface of pancreatic islets is provided to effectively reduce immune response and to induce antithrombogenicity effect. CONSTITUTION: A method for modifying the surface of pancreatic islet comprises: a step of activating PEG or derivatives thereof for conjugation of PEG or derivatives thereof on the surface of the pancreatic islet; a step of conjugating the activated PEG or derivatives thereof with an amine group on the surface; and a step of conjugating the terminal function groups of the PEG or derivatives with the bioactive complex. The bioactive complex is conjugated with heparin or derivatives thereof, and bioactivation materials. [Reference numerals] (AA) Pancreatic islet cells; (BB) Heparin catechol; (CC) 8-armed star shaped PEG