The aldehyde or ketone carbonyl compounds having more than one primary amino group of the reductive amination by more than one with an amine compound to form a product . Aldehyde or ketone compound and product amine compound to react in the presence of an alcohol solvent to form a reaction mixture containing at least one intermediate . Then , to form a product of the reductive amination with the purpose of the intermediate . The method can produce the desired product in very high yield while lowering the concentration of the secondary amine impurity .
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