Synthesis of Bis(8-aminoquinoline)-substituted Tetraazacrown Ethers by a Reductive Amination Process

摘要

Four new tetraazacrown ethers containing two 8-aminoquinoline side arms were prepared first by reductive amination of 8-nitroquinolin-2- carboxaldehyde with the appropriate tetraazacrown ether containing two NH functions (see our Technical Report No. 4). The resulting bis(8-nitro-2- quinolinylmethyl)-substituted tetraazacrown ethers were reduced by iron and HCl to form the N,N'-bis(8-amino-2-quinol inylmethyl)-substituted tetraazacrown ether ligands.