METHOD OF PREDICTING POST-INFARCTION REMODELLING OF LEFT VENTRICLE MYOCARDIUM IN PATINETS WITH MYOCARDIAL INFARCTION

摘要

FIELD: medicine.;SUBSTANCE: invention relates to field of medicine, namely to cardiology. In order to predict post-infarction remodeling of left ventricle (LV) myocardium in patients with myocardial infarction (MI) laboratory blood parameters in said category of patients are analysed. In particular, estimated are levels of N-terminal brain natriuretic peptide precursor (NTproBNP), pg/ml, matrix metalproteinase 9 (MMP9), ng/ml, highly-sensitive C-reactive protein (hs CRP), mg/l, metalproteinase 1 precursor (proMMPI), ng/l and content, %. All parameters are analysed on 3-5 day of disease and remodeling of LV myocardium in patients with MI is predicted by formula: K=0.009×MMP9+0.00032×NTproBNP+0.15×m+0.03×proMMPI+0.08×hsCRP-5.4, where K is prognostic index of post-infarction remodeling of LV myocardium. If value K-0.85, high risk of post-infarction remodelling of LV myocardium in patients with MI is predicted.;EFFECT: method increases accuracy of prediction of post-infarction remodelling of LV myocardium in patients with MI after three months after disease beginning due to correlation analysis between levels of MMP9, proMMPl, hsCRP, NTproBNP and monocytes.;1 tbl, 3 ex