Affinity structures for the specific binding of substances by non-covalent interaction forms

摘要

A method for producing affinity binders with affine or high affinity binding structures for non-covalent forms of interaction, comprising a) contacting a target substance with at least one peptide ligand which is capable of non-covalent binding to the target substance for a sufficient period of time that the at least can attach a peptide ligand specifically to the target regions of the target substance and forms a peptide ligand-target substance complex; b) embedding the complex in a structuring component and fixation by binding the peptide ligand (s) of the complex to the structuring component; c) Removing the target substance, so that a structure with a defined spatial arrangement of the peptide ligand (s) arises, which has the capacity to specifically bind the target substance in question again.