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AFFINITY STRUCTURES FOR THE SPECIFIC BINDING OF SUBSTANCES BY MEANS OF NON-COVALENT INTERACTION SHAPES
AFFINITY STRUCTURES FOR THE SPECIFIC BINDING OF SUBSTANCES BY MEANS OF NON-COVALENT INTERACTION SHAPES
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机译:通过非有效相互作用形状手段对物质进行特定结合的亲和力结构
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摘要
A method for producing affinity binders having affinitive or highly affinitive binding structures for non-covalent interaction types includes a) contacting a target substance with at least one ligand which is capable of non-covalently binding to the target substance for a sufficient time that the at least one ligand can specifically attach to target regions of the target substance and form a ligand-target substance complex; b) embedding the complex in a structure-providing component and fixing by binding the ligand(s) of the complex to the structure-providing component; and c) removing the target substance such that a structure with a defined spatial arrangement of the ligand(s) is formed which has capacity to specifically bind the respective target substance again.
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