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AU RNA-Binding Factors Differ in Their Binding Specificities and Affinities

机译:所有RNa结合因子的结合特异性和亲和力不同

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AUUUA multimers present in the 3'-translated region of mature lymphokine andcytokine transcripts have been implicated in the regulation of mRNA stability and translational efficiency. We have identified RNA-binding factors, termed AU-A, AU-B, and AU-C, that interact with AUUUA multimers. AU-A is an abundant, constitutively expressed 34-kDa factor that localizes primarily to the nucleus. AU-A binds to AUUUA multimers with low relative affinity and also binds to other

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