Producing medicament comprises imaging amplified genome segments in isolated tumor sample, reproducing and sequencing fusion area of fused amplified genome segments in amplicons and providing sample, which specifically bind to fusion area

摘要

Producing an individual specific medicament, comprises (a) high-resolution imaging of amplified genome segments in an isolated tumor sample using fine-tiling array, optionally after previous total genome analysis, preferably CGH (comparative genomic hybridization) analysis, (b) reproducing (preferably by PCR) and subsequent sequencing of the fusion area of the fused amplified genome segments within the amplicons with the amplicon fusion points, and (c) provision of a sample, which allows to specifically bind to the fusion areas. An independent claim is included for a sample, obtained by the above method. ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.