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Fused bicyclic carboxamide derivatives used as CXCR2 inhibitors in the treatment of inflammation

机译:融合的双环羧酰胺衍生物用作CXCR2抑制剂,用于治疗炎症

摘要

The invention relates to compounds of the formula I in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and the pharmaceutically acceptable salts thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts thereof are suitable for the prevention and treatment of chemokine mediated diseases such as inflammation.
机译:本发明涉及式I化合物其中R 1,R 2,X,A,B,D和Y 1至Y 4具有权利要求中所指示的含义,及其药学上可接受的盐。由于它们作为趋化因子受体的抑制剂,特别是作为CXCR2抑制剂的性质,式I化合物及其药学上可接受的盐适用于预防和治疗趋化因子介导的疾病,例如炎症。

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