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Synthesis and Antibacterial Activity of Novel Oxazolidinone Analogs Containing Substituted Thiazole/Fused-Bicyclic Groups

机译:新型含取代的噻唑/稠合双环基恶唑烷酮类似物的合成及抑菌活性

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机译:Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic(imidazo[1,2-b] pyridazine/imidazo[2,1-b]thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate compound 11 was proposed. The structures of the target compounds were confirmed by 1H NMR, IR and MS, and their in vitro antibacterial activities against staphylococcus aureus were evaluated. Among them, compound 16a displays a promising antibacterial activity comparable to that of linezolid.

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