Genetic risk detection method for cerebrovascular disorders

摘要

PPROBLEM TO BE SOLVED: To provide a gene detection method, etc., for acquiring a material for determining genetic risk of ischemic and hemorrhagic cerebrovascular disorders. PSOLUTION: Two hundred and two genetic polymorphisms relating to 152 candidate genes were measured on 1,141 patients of cerebrovascular disorder (636 patients of atherothrombotic cerebral infarction, 282 patients of cerebral hemorrhage and 223 patients of subarachnoid hemorrhage) and 2,010 controls to detect genetic polymorphisms significantly relating to the onset of these 3 diseases. As a result of the investigation, it has been clarified that the risk detection based on 8 genetic polymorphisms for atherothrombotic cerebral infarction, 9 genetic polymorphisms for cerebral hemorrhage and 10 genetic polymorphisms for subarachnoid hemorrhage in addition to the conventional risk factors for cerebrovascular disorder is useful for the primary and secondary prevention of cerebrovascular disorder. Stratified analyses on each of 6 factors comprising the sex, hypertension/hypercholesterolemia/diabetes/obesity/smoking habit revealed that different genetic polymorphisms have relationship to atherothrombotic cerebral infarction. PCOPYRIGHT: (C)2007,JPO&INPIT