compound, pharmaceutical composition, methods of treating or reducing the risk of disease or conditions, treating or reducing the risk of neuroinflammatory disorders, and treating or reducing the risk of cardio and cerebrovascular atherosclerotic disorders or peripheral arterial disease, heart failure and respiratory disorders, and, use of a compound

摘要

COMPOUND, PHARMACEUTICAL COMPOSITION, TREATMENT METHODS OR RISK REDUCTION OF DISEASES OR CONDITIONS, TREATMENT OR REDUCTION OF DISORDERS RISK NEUROJNFLAMATóRIOS AND TREATMENT OR RISK REDUCTION DISORDERS ATEROSCLEóTICOS CARDIO AND CEREBROVASCULAR OR DISEASE peripheral arterial, HEART FAILURE AND RESPIRATORY DISORDERS, AND, USE OF A COMPOUND Here, new compounds of Formula (1) are disclosed in which L, R ', X and Y are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of a MIPO enzyme and are therefore particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio and cerebrovascular atheroscleotic disorders and peripheral arterial disease and respiratory disorders.