In synthetic manner of shigatokishin CTX1B and synthesis of shigatokishin CTX1B useful chemical compounds

摘要

Disclosed is a method for total synthesis of CTX1B, which is developed for the synthesis of a ciguatoxin analogue such as CTX3C and enables the more efficient application of an established reaction to the total synthesis of CTX1B. More specifically, disclosed is a method for total synthesis of CTX1B comprising: an O,S-acetal formation reaction for synthesizing a novel compound (3); a radical cyclization reaction for constructing a 9-membered ring formation reaction including a novel compound (6) through a novel compound (8) and yielding a compound (D); and a deprotection reaction for yielding CTX1B. Also disclosed are novel compounds (1) to (8) which are particularly useful for the synthesis of CTX1B and can be used for the synthesis of a ciguatoxin analogue.