metastine derivative or salt thereof, compound or salt thereof, prodrug, medicament, and use of an effective dose of the metastine derivative

摘要

METASTINE DERIVATIVE OR A SALT OF THE SAME, COMPOUND OR A SALT OF THE SAME, PRE-DRUG, MEDICINE, AND USE OF AN EFFECTIVE METHODINE DERIVATIVE DOSE The present invention provides stable metastine derivatives having excellent biological activities (a suppressive activity metastasis, a cancer growth suppressing activity, a gonadropropic hormone secretion stimulating activity, sex hormone secretion stimulating activity, etc.) by stimulating the metastine constituent amino acids with specific amino acids in the metastine derivative of the present invention, blood stability, solubility, etc. are further improved, gelation tendency is reduced, pharmacokinetics are also improved and excellent cancer metastasis suppression activity or cancer growth suppression activity is exhibited. In addition, the metastine derivative of the present invention has the effects of suppressing gonadotropic hormone secretion, suppressing sex hormone secretion, etc.