microelectronic sensor device, method for investigating at least one biologically target substance, and, use of microelectronic sensor device

摘要

MICRO-ELECTRONIC SENSOR DEVICE, METHOD FOR INVESTIGATING AT LEAST ONE BIOLOGICAL TARGET SUBSTANCE, AND USE OF THE MICRO-ELECTRONIC SENSOR DEVICE. The invention relates to a microelectronic sensor device and a method for investigating biological target substances (20), for example, oligonucleotides as fragments of DNA. In one embodiment, the device comprises a reaction surface (RS) to which specific target reagents (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired, to provide, for example, conditions for a PCR and / or for a controlled fusion of the hybridizations. The reagent (10) and / or the target substance (20) comprise a label (12) with an observable property, such as fluorescence that changes if the target substance (20) is attached to the reagent (10), said property being detected by a arrangement of sensor elements, for example, photo sensors (SE). The fluorescence of the label (12) can preferably be transferred by FRET to a different fluorescent label (22) or extinguished if the target substance (20) is bound.