Process for preparation of (e)-5-(2-bromovinyl)-2'-deoxyuridine

摘要

Process of preparing (E)-5-(2-bromovynyl)-2'-deoxyuridine (Brivudine) characterized in that halogen-free solvent selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2'-deoxyuridine diacylate. The use of solvents is advantageous in respect of toxicity, discharge costs and environment protection.