HLA-B5801 ALLELE ASSOCIATED WITH ADVERSE DRUG REACTIONS AND METHODS FOR DETECTING SUCH

摘要

597628 Disclosed is a method of assessing a risk of a human patient for developing an adverse drug reaction in response to a drug, comprising: Detecting the presence of HLA-B*5801 in a sample obtained from the patient; and Correlating the presence of HLA-B*5801 in the sample with an increased risk for an adverse drug reaction in the patient in response to the drug, wherein the adverse drug reaction is Stevens-Johnson syndrome or toxic epidermal necrolysis and the drug is oxypurinol.