Crystalline forms of 3 - (2, 6 Dichloro - 3, 5 - dimethoxy phenyl) - 1 - (6 - 4 - (ethyl - piperazin-1-yl) - amino - phenyl - pyrimidin-4-yl} - 1 - Methyl urea and salts thereof

摘要

Refers to a compound of formula (i) where: (a) The anhydrous Crystalline form shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately 12, 10.5u00ba, 15.2u00ba, 19.5u00ba and 21.Package; (b) the manner of Monohydrate Crystal shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately 20.3u00ba, 21.3u00ba, 18.8u00ba, 4.7u00ba, 9.4u00ba and 11.Package; (c) The Crystalline Salt anhydrous acid monofosforico shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately: Fifteenth, 13.7u00ba, 16.8u00ba, 21.3u00ba, 22.4u00ba, 9.2u00ba, 9.6u00ba, 18.7u00ba, 20.0u00ba, 22.9u00ba and 27.2; (d) The hydrochloride Salt shows a diffraction Pattern in x-ray Powder comprising one or more peaks at 2 Theta terms selected from peaks at approximately 10.9u00ba, 12.1u00ba, 14.8u00ba, 20.5u00ba, Twenty second and 25.1u00ba. It also relates to a Pharmaceutical composition. This Compound is an inhibitor of kinase FGFR1, FGFR2, FGFR3, fgfr4, kdr, HER1, HER2, bcr abl, Tie2 and ret.To be useful for the treatment of cancer