METHOD FOR IN-VITRO SELECTIVELY INDUCING APOPTOSIS OR INHIBITING PROLIFERATION OF TARGET CELLS EXPRESSING DR5 AND COMPOSITION FOR SELECTIVELY INDUCING APOPTOSIS, WHICH COMPRISES A COMBINATION OF ANTIBODIES

摘要

The invention relates to combinations of antibodies selective for a tumor necrosis factor -related apoptosis-inducing ligand receptor. An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream the cascade reaction of the receptor, including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are intended to be used in the treatment of apoptosis-related diseases and treatment of dysregulated cell growth.