Compounds and compositions for the treatment of multiple myeloma.

摘要

Compounds and compositions for the treatment of multiple myeloma. # The present invention relates to compounds inhibiting enzyme carnitine palmitoyl transferase I (CPT I) and their therapeutic use and to compositions and low density lipoproteins (LDLs) comprising one or more inhibiting compounds enzyme carnitine palmitoyl transferase I (CPT I), one or more 26S proteasome inhibitors, compositions and LDLs comprising one or more inhibitory compounds enzyme carnitine palmitoyl transferase (CPT I), one or more inhibitors of gastric lipase and / or pancreatic and optionally one or more 26S proteasome inhibitors. The invention also relates to the use of such compositions and LDLs in treating a disease that causes uncontrolled proliferation of plasma cells, and more specifically in the treatment of multiple myeloma.