ACTIVATING TRANSCRIPTION FACTOR 3 WHICH IS USED AS A NOVEL THERAPEUTIC TARGET AND FOR PREDICTING TOXICITY

摘要

PURPOSE: Activating transcription factor 3 (ATF3) is provided to show enhanced activity by a chemotherapeutic agent for anticancer, thereby being used as a marker for predicting toxicity in organs.;CONSTITUTION: A method for predicting cytotoxicity comprises the steps of measuring the gene expression level or protein level of ATF3 in a biological sample; and comparing the gene expression level or protein level of ATF3 in the biological sample with the gene expression level or protein level of ATF3 in a control group. A composition reducing cytotoxicity contains an ATF3 expression inhibitor.;COPYRIGHT KIPO 2013