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METHOD FOR PREPARING BETULIN 3-ACETATE-28-SULPHATE SODIUM SALT
METHOD FOR PREPARING BETULIN 3-ACETATE-28-SULPHATE SODIUM SALT
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机译：制备甜菜碱3-乙酰-28-硫酸钠的方法
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摘要
FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to chemical-pharmaceutical industry and concerns a method for preparing betulin 3-acetate-28-sulphate sodium salt that is a biologically active substance being of the utmost interest for medicine. Betulin 3-acetate is sulphated in 1,4-dioxane by the SO3-dioxane complex at temperature 20-30°C for 2-3 hours; the reaction mixture is thereafter processed in 75% water-ethanol solution containing 4% sodium hydroxide to pH 7-8 to recover an end product.;EFFECT: synthesis of new water-soluble sulphated betulin derivatives, extended range of the sulphatising agent, simplified process ensured by using liquid SO3.;1 cl, 1 ex
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机译：领域：本发明涉及化学-制药工业，并且涉及一种制备3-乙酸-28-硫酸间苯三酚白蛋白的方法，其是对医学最感兴趣的生物活性物质。 SO 3 -二恶烷络合物在20-30°C的温度下将3-Betulin-acetate在1,4-二恶烷中硫酸化2-3小时;然后将反应混合物在含有4％氢氧化钠的75％水-乙醇溶液中处理至pH 7-8，以回收最终产物。效果：合成了新型的水溶性硫酸化桦木素衍生物，扩大了硫酸化剂的使用范围，简化了操作液态SO 3 确保工艺流程; 1 cl，1 ex
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