TAUROLIDINE FORMULATION AND DELIVERY: THERAPEUTIC TREATMENT AND ANTIMICROBIAL PROTECTION AGAINST BACTERIAL MICROFILM FORMATION

摘要

PROBLEM TO BE SOLVED: To provide: (i) therapeutic treatment of infection; and (ii) attachment, and/or colonization, or eradication of colonization, on device surfaces which store or convey microbes to body fluids or contact tissue; or (iii) extracorporeal blood processing treatment to treat sepsis.SOLUTION: Treating of localized bacterial infection comprises locally applying taurolidine to an infected area. A device for insertion into the body comprises taurolidine to render the device infection resistant. A medication for treating bacterial infections comprises taurolidine carried by one of gel, liquid, thixotropic gel, colloidal mixtures, dispersal suspensions, injectable polymers or microparticles. Furthermore, a method for treating blood comprises: removing blood from a body; treating the blood with taurolidine; and returning the treated blood.