The present invention is the blood of a subject, determining the presence of a fluorescent analyte with fluorescent substance and a second entity, to quantify blood levels, and / or blood clearance monitoring or non-invasive determining a method, (a) to excite the fluorescent substance, irradiating the excitation light of at least one predetermined wavelength to said subject comprising at least a portion of the pupil specified region, ( b) through the eye of the subject, it receives the light emitted from the fluorescent analytes having a wavelength and distinguishable predetermined wavelength of (a), the fluorescence analysis of the blood of the subject by this to determine the presence of things, to quantify the blood levels, and / or a blood clearance comprising a monitor or determining step or consisting of. The present invention further provides, for use in any one of the methods, for fluorescent analytes or fluorescent labels as defined in any one of the preceding claims. The present invention further provides for the adjustment of a diagnostic composition for use in any one of the methods, the use of the fluorescent analyte and fluorescent labels as defined in any one of the preceding claims. The present invention further relates to apparatus for use in any method as defined herein.
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