Improved synthesis of (2S-cis) -2- (bromomethyl) -2- (4-chlorophenyl) -1,3-dioxolane-4-methanol methanesulfonate (ester)

摘要

The present invention relates to an improved process for the preparation of (2S-cis)-2-(bromomethyl)-2-(4-chlorophenyl)-1,3-dioxolane-4-methanol methanesulfonate(ester), a key intermediate for the preparation of the apoB secretion/MTP inhibitor mitratapide.