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Biosensor and use thereof to identify therapeutic drug molecules and molecules binding orphan receptors
Biosensor and use thereof to identify therapeutic drug molecules and molecules binding orphan receptors
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机译:生物传感器及其在鉴定治疗药物分子和结合孤儿受体的分子中的用途
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摘要
G protein biosensors comprising mammalian G protein subunits fused to fluorescent proteins emitting a FRET signal expressed in living intact functional cells. The intensity of the FRET signal is strongly responsive to the activation state of the biosensors. The biosensors respond reproducibly to agonist and antagonist drug molecules specific for G protein coupled receptors. The biosensors have utility in identifying and classifying candidate therapeutic drugs as to their therapeutic value.
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