首页> 外国专利> Crystalline form of Ester 5 - methyl - 2 - oxo - 1,3 - 4 - ilmetilico dioxol acid (2S, 4R) - Diphenyl - 4 - 5 - Hydroxymethyl - il - 2 - methyl - 4 - 2 - (1H - 1,2,3 triazol 4 - amino carbonyl) pentanoic acid

Crystalline form of Ester 5 - methyl - 2 - oxo - 1,3 - 4 - ilmetilico dioxol acid (2S, 4R) - Diphenyl - 4 - 5 - Hydroxymethyl - il - 2 - methyl - 4 - 2 - (1H - 1,2,3 triazol 4 - amino carbonyl) pentanoic acid

机译：酯5-甲基-2-氧代-[1,3]-4-乙美特二酸（2S，4R）-联苯-4-5-羟甲基-il-2-甲基-4-[2-（1H -[1,2,3]三唑4-氨基]羰基）戊酸

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摘要

A Crystalline acid (2S, 4R) - Diphenyl - 4 - 5 - Hydroxymethyl - il - 2 - methyl - 4 - [2 - (1H - [1,2,3] triazol 4 - amino] carbonyl) pentanoic acid ester 5 - methyl - 2 - oxo - [1,3] - 4 - ilmetu00edlico or dioxol tautu00f3mero. Also provides Pharmaceutical compositions comprising Crystalline Compound, processes and Intermediates for preparing Crystalline Compound, and its use to treat diseases.Claim 1: Ester 5 - methyl - 2 - oxo - [1,3] - 4 - ilmetu00edlico dioxol acid (2S, 4R) - Diphenyl - 4 - 5 - Hydroxymethyl - il - 2 - methyl - 4 - [2 - (1H - [1,2,3] triazol 4 - amino] carbonyl) pentanoic acid Crystal characterized by a diffraction pattern that includes x-ray Powder diffraction Peaks in Val Pray 2Q 8.62 (9.50 + 0.20, 0.20, 12.14 (15.18 (0.20, 0.20, 0.20 (15.72, 19.90 (20,40 (0.20, 0.20,And 25.70 (23,42 (0.20, 0.20.

机译：结晶酸（2S，4R）-二苯基-4-5-羟甲基-il-2-甲基-4-[2-（1H-[1,2,3]三唑4-氨基]羰基）戊酸酯5-甲基-2-氧代-[1,3]-4-ilmet edlico或dioxol绷紧 u00f3mero。还提供了包含结晶化合物的药物组合物，制备该结晶化合物的方法和中间体及其在疾病中的用途。权利要求1：酯5-甲基-2-氧代-[1,3]-4-ilmet ededoo二氧戊酸（2S），4R）-二苯基-4-5-羟甲基-il-2-甲基-4-[2-（1H-[1,2,3]三唑4-氨基]羰基）戊酸晶体，其特征在于具有如下衍射图谱： Val Pray 2Q中的X射线粉末衍射峰8.62（9.50 + 0.20，0.20，12.14（15.18（0.20，0.20，0.20（15.72，19.90（20,40（0.20，0.20，and 25.70（23,42（0.20，0.20）。

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公开/公告号AR089954A1

专利类型
公开/公告日2014-10-01

原文格式PDF
申请/专利权人 THERAVANCE INC.;
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申请/专利号AR2013P100412
发明设计人 MIROSLAV RAPTA;
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申请日2013-02-08
分类号C07D405/12;A61K31/4192;A61P9/04;A61P9/12;A61P13/12;
国家 AR
入库时间 2022-08-21 15:58:51

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