SPYRO- 1,3 -OXAZINS AND SPYRO- 1,4 -OXAZEPINS AS BACE1 AND / OR BACE2 INHIBITORS

摘要

The invention provides spiro [1,3] -oxazines and spiro [1,4] -oxazepines of the formula I possessing inhibitory activity against BACE1 and / or BACE2, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic or prophylactic treatment of, for example, Alzheimer's disease and type 2 diabetes.