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Spiro-1,3-oxazines and spiro-1,4-oxazepines as bace1 and/or bace2 inhibitors
Spiro-1,3-oxazines and spiro-1,4-oxazepines as bace1 and/or bace2 inhibitors
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机译:螺-[1,3]-恶嗪和螺-[1,4]-奥氮平作为bace1和/或bace2抑制剂
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摘要
The present invention provides spiro-[1,3]-oxazines and spiro-[1,4]-oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
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