Spiro-1,3-oxazines and spiro-1,4-oxazepines as BACE1 and/or BACE2 inhibitors

摘要

The present invention provides spiro-[l,3]-oxazines and spiro-[l,4]-oxazepines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.