Design and Preparation of 1H-3,4-Dihydropyrrolo1,2-aPyrazin-1-one via 1H-3,4-Dihydropyrrolo1,2-c1,4Oxazin-1-one Route

摘要

With 2-pyrrolyltrichloroacetone as major starting material, unreported 1H-3,4-dihydropyrrolo-[1,2-a]pyrazin-1-one was prepared successively by its monoesterification with ethylene glycol, bromine displacement of hydroxy group, cyclization to lactone and its amidation. Unreported 7-aroyl-1H-3,4-dihydropyrrolo[1,2-c][1,4]oxazin-1-one compounds were also synthesized in turn by 2-pyrrolyl-trichloroacetone's Friedel-Crafts acylation and cyclization. Their structures were characterized by IR, 1H NMR, 13C NMR, MS, HRMS, etc.