Substitution of 6-amino-nicotine for knq2 / 3 modulator

摘要

6-amino-nicotine formula (I) derivative,R1 is liquid residue of C1-C10, C3-C10, etc.; R2 is liquid residue of F, Cl, Br, CN, CF3, etc.; R4 is liquid residue of C1-C10, C3-C10, etc.; R5 is liquid residue of H or C1-C10; R6 is alifatic residue of C2-C6, C1 Alic, etc. - 1-1-1-1-1-1-1-1-1-1-1-1-1-4-4-4-methyl-4-4-3-amino acid anthrax amide,There are others These compounds are knk2 / 3K + channel modulators, which can be used to treat acute pain, chronic pain, neuralgia and so on.