2-oxo-y 2-tioxo-dihydroquinalina-3-carboxamides replaced by knq2 / 3 modulator

摘要

It refers to 2-O x o-y 2-tioxo-dihydroquinolina-3-carboxamis derivative, which is replaced by formula (I) of X or s; R1 is alifatic residue (C1-C10),Cyclododecane (C3-C10),Among others, R2 is f, Cl, CN, CF3; R3, R4, R5 and R6 are h, F, C (= O) h, C (= O) - Oh, ScF3, NO2, etc.; R7 is alifatic residue (C1-C10),Cyclododecane (C3-C10),There are others The most popular compounds are: 1,4-dimethyl-2-oxo-7 - (sulfur trifluoride) - 1, h-quinoline-3-carbohydrates; 1-butyl-n - [(sulfur trifluoride) - methyl] - 4-methyl-2-oxo-7 - (sulfur trifluoride) - 1, h-quinoline-3-carbohydrates; Acid-3 - [nile-1] - fluorine; 4-dimethyl-2-thio-7 - (trifluoromethyl) - 1h-quinoline-3-anthrax, etc. He also mentioned a pharmaceutical composer These compounds are knk2 / 3K + channel modulators for the treatment of acute pain, neuralgia, muscle pain, anxiety