N-desulfated derivatives as inhibitors of heparanase fully glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulant effect

摘要

Heparin N-reacetylated totally N-desulfated of formula (1) wherein ring U has the following meaning R and R1 are acetyl residue; X and X 'are the -CH2-D group, where D is hydroxyl; n and m, which may be the same or different, may vary from 1 to 40; the sum of n + m varies from 6 to 40, the m: n ranges from 10: 2 to 1: 1, the symbol indicates that the units marked m and n estánestadísticamente distributed along the polysaccharide chain and are not necesariamentesecuenciales .