DERIVATIVES OF PARTIALLY DESULPHATED GLYCOSAMINOGLYCANS AS HEPARANASE INHIBITORS, ENDOWED WITH ANTIANGIOGENIC ACTIVITY AND DEVOID OF ANTICOAGULATING EFFECT

摘要

PROBLEM TO BE SOLVED: To find optimal glycosaminoglycan structures for generating antiangiogenic activity based on heparanase inhibition and/or FGF growth factor inhibition mechanisms, and to provide a medicament with antiangiogenic activity which is essentially devoid of the typical side effects of heparin derivatives, such as anticoagulant activity.;SOLUTION: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R₁ groups have the meanings indicated herein. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.;COPYRIGHT: (C)2016,JPO&INPIT