Method for producing 3,4-disubstituted pyrrolidine derivative and production intermediate thereof

摘要

Disclosed is an economical and industrially advantageous method for producing a (3R,4S)-3-(N-substituted-aminomethyl)-4-fluoropyrrolidine, which is usable as an intermediate in producing a medicine, or an enantiomer thereof. Specifically disclosed is a method for producing a (3R,4S)-3-(N-substituted-cyclopropylaminomethyl)-4-fluoropyrrolidine derivative, an enantiomer thereof or a salt of the same, comprising a step for fluorinating a 4-hydroxy-3-(N-substituted-aminomethyl)pyrrolidine derivative represented by general formula (1) or an enantiomer thereof by using a sulfur tetrafluoride derivative. In general formula (1), PG represents a protecting group for the amino group; and R