Novel Methods for the Stereoselective Synthesis of Oxetane, Azetidime and Pyrrolidine Derivatives

摘要

Novel, superbase promoted stereoselective rearrangement reactions of chiral oxirane derivatives provided chiral oxetane and azetidine derivatives. An optically active 3,4-disubstituted pyrrolidine was synthetised via catalytic hydrogenolysis of an oxetane derivative followed by ring closure of the formed optically active aminoalcohol.