METHODS OF TARGETING MIR-223 EXPRESSION TO ABLATE LEUKEMIC CELLS

摘要

Described herein are methods and compositions for the treatment of leukemia in a subject. Also described herein are methods and compositions for the improvement of anti-cancer therapy such as chemotherapy and radiation therapy. In certain embodiments, the agent is an antagomir of miR-223, an anti-miR-223 oligonuleoctide, an antisense oligonucleotide to miR-223, or a double-stranded RNA that complementary base-pairs with miR-223.