Expression and function of CXCR2, CXCR7 of acute leukemic cells in rat

摘要

Objective:To investigate the expression and function of chemokine receptorCXCR2 andCXCR7 in the rat with acute leukemia.Methods:Flow cytometry andRT-PCR were used to detect the CXCR2,CXCR7 expression on the bone marrow cell surface of the acute leukemia group and the control group.Results:The bone marrow cell surfaceCXCR2,CXCR7 relative fluorescence intensity of the observation group was significantly higherthan the control group(P<0.05).The CXCR7 expression of the extramedullary infiltration group was significantly higher than non-extramedullary infiltration group(P<0.05).TheCXCR2,CXCR7mRNA median expression level of the observation group was higher than the control group.TheCXCR2 expression andCXCR7 expression of the observation group was positively correlated, and the correlation coefficient was 0.782(P<0.01).Conclusions:The chemokine receptorCXCR2 andCXCR7 are highly expressed in acute leukemia, which may be associated with the occurrence of leukemia.