ANTI-PROLIFERATIVE BTG2 (B-CELL TRANSLOCATION GENE 2) PROTEIN REGULATING MITOCHONDRIAL ACTIVITIES AND THE USE THEREOF

摘要

The present invention relates to a suppression composition regulating cell proliferation by the use of Btg2, which comprises gene transporters including first rank nucleic acid molecules out of a ranking list targeting mitochondria through second rank nucleic acid molecules out of the ranking list. The inventors of the present invention have discovered that Btg2 known as a nucleoprotein, also exists in mitochondria, and confirmed that Btg2 targeted to mitochondria through a specific ranking (the second rank of the ranking list of the present invention) reduces production of ATP and increases production of reactive oxygen species (ROS) by being incorporated into Ant2 involved in the production of energy in mitochondria. As the inventors provide an effect of regulating cell proliferation by the use of the composition of the present invention, possibility of regulating proliferation of cancer cells dependent on Btg2 is provided. Specifically, an anti-cancer effect for ovarian cancer or cervical cancer and an anti-cancer effect more enhanced by the gonadotropin hormone are provided.