Anti-Proliferative Btg2 (B-cell Translocation Gene 2) Protein Regulating Mitochondrial Activities and the Use Thereof

摘要

The present invention relates to a novel cell proliferation inhibiting composition using Btg2, which comprises a cell proliferation inhibitor comprising a gene carrier comprising a nucleic acid molecule of the first sequence of the sequence listing targeted to the mitochondria by the nucleic acid molecule of the second sequence of the sequence listing, / RTI We found that Btg2, also known as the nuclear protein, is also present in mitochondria, and Btg2 targeted to mitochondria by a particular sequence (SEQ ID No. 2 of the present invention) And decreased production of ATP and increased production of reactive oxygen species (ROS). The present inventors intend to propose a possibility of inhibiting Btg2-dependent cancer cell proliferation by providing a cell proliferation inhibitory effect using the composition of the present invention. In particular, the present inventors intend to propose an anticancer effect in ovarian cancer or cervical cancer and a more advanced anti-cancer effect by gonadotropin Effect.